Trazodone for insomnia ratings8/28/2023 selective serotonin reuptake inhibitors (SSRIs).You may have heard of the more common antidepressant types that work to increase serotonin levels: Serotonin is a chemical that’s produced in the brain and it’s important for regulating our mood and happiness.ĭrugs that increase the levels of serotonin have long been used to treat depression. It’s not fully known how this drug works, but it’s thought to block nerve cells in the brain from taking up serotonin. 7 It wasn’t until 1981 that it was approved for use in the USA for the treatment of MDD. Trazodone was developed in the 1960s in Italy as a drug to treat depression and has been used to treat major depressive disorder (MDD) since the 1970s. We’ll begin with a look at the history of trazodone and its usage. In this article we’ll share key facts about the background of this drug, explain why it’s used as a sleep medicine, what the risks of taking it are and whether it is helpful as a treatment for insomnia. So what is it about trazodone that has led to it being considered a useful sleep medication by some and not others? In the UK it’s also not licensed as a sleeping pill and is not recommended for the treatment of insomnia. This means that it’s being used to treat a problem that it’s not been licensed for. It was developed as an antidepressant medication and is used ‘off-label’ for insomnia. Yet trazodone is not licensed as a treatment for insomnia in America and guidelines from the American Association of Sleep Medicine explicitly state that it should not be used for insomnia. In fact, trazodone has been one of the most widely prescribed sleep aids in the USA over the past decade figures suggest that nearly 20% of Americans with insomnia are prescribed this drug to help them sleep.
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